Associated with eosinophilia, asthma is a predominant respiratory symptomENT – allergic symptoms, non-destructiveLungs – infiltrates and nodules, DAH rarely seen but also may occurKidney – occurs less likely and a lesser degreeHeart – often involved and associated with damage and higher mortalityANCA – mainly MPO, but detected only in about 40% of patientsHistology – granulomatous inflammation usually accompanied by eosinophils, eosinophilic vasculitis. This evidence concerns the gene MPO and Increased total eosinophil count.