Furthermore, Tbx3:Tbx5 double-conditional knockout mice (Tbx3fl/fl;Tbx5fl/fl;R26EYFP/+;MinKCreERT2/+) showed significantly increased susceptibility to ventricular tachycardia following burst stimulation in invasive electrophysiology (EP) studies (3 of 3 Tbx3fl/fl;Tbx5fl/fl;R26EYFP/+;MinKCreERT2/+ mice versus 0 of 7 littermate controls; (Figure 2H, P<0.05, Welch t test). Here, TBX5 is linked to ventricular tachycardia.