GPI and Parkinsonism: Also, Leblois et al.’s observation that perimovement decreases in firing become less common in parkinsonism could be seen as consistent with Nambu et al.’s (40) dynamic version of the classical rate model, in which under-activation of the GPi-inhibiting direct pathway (the “pro-kinetic” pathway) and over-activation of GPi-exciting indirect pathways (“anti-kinetic” pathways) work together to yield deficient perimovement decreases in GPi activity and concommitent inadequate disinhibition of GPi-recipient motor circuits (41).