The allergic reaction could be divided into two different phases, an early step starts from the moment in which the allergen binds to the mast cell with its specific IgE receptors, causing mast cell degranulation, which in turn releases the main molecule mediators responsible for the symptoms typical of immune responses, such as histamines, proteases, proteoglycans, and tumor necrosis factor-alpha (TNF-α) (3). This evidence concerns the gene TNF and allergic disease.