S100A6 and neoplasm: By comparing their expression in tumor and non-tumor tissues from the TCGA-LIHC database, we found that all core DEGs were upregulated in tumoral specimens (Figure 12A); moreover, HMGN4 (log-rank p= 0.039) and S100A6 (log-rank p= 0.014) expressions in HCC patients were significantly correlated with their overall survival (Figure 12B), suggesting their tumorigenic potential in liver fibrosis progression.