S100A6 and alcoholic liver cirrhosis: By comparing their expression in HCV- and alcohol-related cirrhosis, we found that most of the core DEGs were significantly upregulated in HCV- and alcohol-related cirrhosis; specifically, S100A4 and S100A6 were upregulated in HCV-related cirrhosis but presented comparable expression in alcoholic cirrhosis and control livers (Figures 11A, B).