CD244 and type 1 diabetes mellitus: (96), have demonstrated that autoreactive CD8+ T-cell exhaustion, with expression of eomesodermin (EOMES), programmed cell death (PD)-1, T-cell immunoreceptor with Ig and ITIM domains (TIGIT), CD244 (also known as 2B4), and CD160 may be used to discriminate subjects with slow T1DM progression.