(96), have demonstrated that autoreactive CD8+ T-cell exhaustion, with expression of eomesodermin (EOMES), programmed cell death (PD)-1, T-cell immunoreceptor with Ig and ITIM domains (TIGIT), CD244 (also known as 2B4), and CD160 may be used to discriminate subjects with slow T1DM progression. Here, CD8A is linked to type 1 diabetes mellitus.