Additionally, tumor proliferation regulator and metabolic genes implicated in glycolysis and gluconeogenesis pathways, including VEGFA, CCN1, VIM, LDHA, LDHB, PKM, ENO1, and PGK1, were up-regulated in HG OPC-like subclusters (data not shown), indicating an increase in stress response during the gliomagenesis. This evidence concerns the gene CCN1 and neoplasm.