Meanwhile, genes that have functions in the normal brain or neurons, such as CaMK2N1 (Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 1), MEG3 (Maternally Expressed 3), SNCB (Synuclein Beta), SYT1 (Synaptotagmin 1), DKK3 (Dickkopf WNT Signaling Pathway Inhibitor 3), are almost not expressed in the tumor core. The gene discussed is DKK3; the disease is neoplasm.