These results were confirmed by binary logistic regression analysis, suggesting that the levels of Th1 (OR 0.8690; 95% CI 0.7823 to 0.9652; p=0.0090), as well as the expression levels of IL-4 from CD4+ Th2 cells (OR 1.2099; 95% CI 1.0059 to 1.4554; p=0.0430) and IL-13 from CD4+ Th22 cells (OR 0.9389; 95% CI 0.8860 to 0.9950; p=0.0330) were positively correlated with the occurrence of severe COVID-19 (Table 2B). This evidence concerns the gene IL4 and COVID-19.