Independent risk factors contributing to unplanned reoperations following LPD include a pre-operative serum prealbumin level below 0.15g/L, elevated C-reactive protein (CRP) levels on the POD-7, soft pancreatic texture, and a main pancreatic duct diameter of ≤3 mm. The gene discussed is TTR; the disease is disseminated peritoneal leiomyomatosis.