Finally, the interaction term relating to current distress level due to each interpersonal traumatic event and each NR3C1 CpG site in relation to personality vulnerability to depression was significant on CpG 3 and 4 (B = 0.50, CI95% 0.01–0.60, B = 0.70, CI95% 0.16–1.24, respectively). This evidence concerns the gene NR3C1 and major depressive disorder.