As for model A, the discrimination of ischemic stroke compared with other patients was not increased by the inclusion of circulating tPA levels as a biomarker in the model (0.65, 95% CI [0.59 to 0.70] without tPA and 0.65, 95% CI [0.59 to 0.70] with tPA; p = 0.6072; Fig. 6A,D). This evidence concerns the gene PLAT and ischemic stroke.