An inverted duplication (tail-to-tail) of ∼1.5 Mb (encompassing the ABCA8, ABCA9, ABCA6, ABCA10, ABCA5, MAP2K6 and KCNJ2/KCNJ16 genes; Figure S8) was identified in a patient with extreme congenital generalized hypertrichosis terminalis, coarse face, and gingival hyperplasia.30 Here, MAP2K6 is linked to gingival disorder.