MAPK8 and hemorrhagic stroke: In addition, when BV2 cells were co-cultured with platelets derived from hemorrhagic stroke patients, the levels of COX-2, IL-1β, and p-JNK were found to be higher compared with BV2 cells in the presence of healthy platelets (Figures 5A–5D), suggesting that platelets derived from hemorrhagic stroke patients might induce a greater shift of microglia toward a pro-inflammatory phenotype.