RRM2 and malignant colon neoplasm: According to Liu Q et al. [9], there is a correlation between the expression of the oncogenic transcription factor MYBL2 and the up-regulation of RRM2 expression in colon cancer, and MYBL2 is able to bind directly to the promoter region of the RRM2 gene to promote its transcription, which then regulates the proliferation mechanism of cancer cells.