Subjects with H. pylori seropositivity constituted a larger proportion in the hyperglycemic group (p < 0.001) and had higher fasting plasma glucose (p = 0.006), serum insulin (p = 0.018) and homeostatic model assessment for insulin resistance (HOMA-IR) concentrations (p = 0.007) than subjects expressing seronegativity. This evidence concerns the gene INS and Insulin resistance.