Interestingly, through analyzing publicly available HCC scRNA-seq datasets (GSE149614, GSE156625, and GSE202642)8,51,52, we found that PRMT3 was mainly expressed in HCC cells in tumor niche and its expression levels in immune cells and stroma cells were much lower than in tumor cells (Supplementary Fig. 14). Here, PRMT3 is linked to hepatocellular carcinoma.