Interestingly, PRMT3-OE led to a small but significant increase in the tumor volumes and weights and a decrease in T cell infiltration (CD4+, CD8+, and IFNγ+ and GZMB+ CD8+ T cells) in HSP60-R446K OE cells compared to vector control (Fig. 5I–O). This evidence concerns the gene PRMT3 and neoplasm.