Since we showed that Myc/Trp53-/- spontaneous tumors had a relatively “cold” TME with fewer T cell infiltration than the Hepa1-6 model (Supplementary Fig. 4C, D), we decided to test whether PRMT3 inhibition could suppress the growth of this immunologically “cold” HCC model and reprogram the relative “cold” TME into “hot” TME by inducing T cell infiltration. This evidence concerns the gene PRMT3 and hepatocellular carcinoma.