HSPD1 and neoplasm: We found that HSP60-WT OE or R446K OE in the absence of PRMT3 overexpression did not promote tumor progression in Prmt3-KO Hepa1-6 cells compared to vector control, as reflected by the similar tumor volumes and tumor weights (Fig. 5I–K) and comparable T cell infiltration (Fig. 5L–O).