MYC and hepatocellular carcinoma: We also observed an increase in interferon-stimulated genes (ISG) (e.g., Cxcl9, Cxcl10, Cxcl11) and IFNβ production in tumors from Myc/Trp53−/− mice treated with PRMT3 inhibitor, an in PRMT3-KO mouse and human HCC cells (Hepa1-6 and PLC-8024) (Fig. 6K, L and Supplementary Fig. 9J–L).