The downregulation of miR-21-3p, miR-130b-3p, and miR-155-5p via the IL6/JAK/STAT signaling pathway in CTCL cell lines resulted in decreased CTCL cell proliferation and increased CD8 (+) T cell-mediated cytotoxic activity [33]. This evidence concerns the gene IL6 and primary cutaneous T-cell non-Hodgkin lymphoma.