In breast invasive carcinoma, adrenal cortical carcinoma, adrenal carcinoma, and a variety of malignant tumors, including ESCC, we discovered that ID3 was positively correlated with many immune cells (CD8 T cells, NK cells, DCs, macrophages, etc.), whereas CD52 was significantly positively correlated with all immune cells in almost all malignancies, and ESCC was no exception (Supplementary Fig. 3A). The gene discussed is ID3; the disease is esophageal squamous cell carcinoma.