IGFBP2 and neoplasm: It was also discovered that GSB, DCN, and CLU were highly expressed at the start of the development trajectory while PLAT, IGFBP2, MMP11, and WNT5A were highly expressed at the end of development, suggesting that they may be involved in the conversion of normal fibroblasts into CAFs and promote the progression of the tumor (Supplementary Figure 5D).