LRRC7 and autism: Here, we identify a group of 33 patients (including one of the previously published cases20), each of whom carries a rare missense or predicted loss-of-function (pLoF) variant in LRRC7. Patients are affected by a syndrome characterised by ID, autism, attention deficit hyperactivity disorder (ADHD) and other behavioural features, including aggressiveness and impulsivity.