SRSF1 and systemic lupus erythematosus: Has-mir-10b-5p regulated SRSF1 transcription and down-regulated SRSF1 protein expression by inhibiting the 3’-UTR activity of SRSF1, resulting in T cell activity and enhanced autoimmunity.401 The expression of has-miR-10b-5p in healthy women T cells was higher than that of healthy men, and the expression of has-miR-10b-5p in systemic lupus erythematosus patients T cells was also higher, resulting in immune response activation.401 In conclusion, DNA methylation, demethylation, and miRNA regulation of immune response may help explain sex differences in autoimmune diseases.