Study has shown that H3K27me3 demethylase UTX, as a tumor suppressor gene, made a protective effect on T-all.245 OTUB1 (ovarian tumor associated proteinase B1) is an OTU superfamily deubiquitination enzyme that specifically inhibited the deubiquitination of c-MYC proteins linked to K48 and K63, thereby accelerating cardiomyocyte apoptosis, inflammation response, and oxidative stress. The gene discussed is KDM6A; the disease is neoplasm.