DNMT inhibitors/low methylation agents 5-aza-2 ‘- deoxycytidine (AZA) and EGFR targeted drugs prevented ovarian cancer progression by altering EGF mediated DNMT activity and overall methylation.240–243 Histone lysine specific demethylase 5D (KDM5D) could be one of the important epigenetic modifiers that gave rise to male gastric cancer poor prognosis. The gene discussed is DNMT1; the disease is ovarian carcinoma.