In addition, E2 increased the activation of IFN-α signal transduction in B cells by decreasing let-7e-5p, miR-98-5p and miR-145a-5p expression and regulating kappa B kinase ε (IKKε) level in systemic lupus erythematosus.400 The expression of serine/arginine-rich splicing factor 1 (SRSF1) was decreased in systemic lupus erythematosus patients. Here, IKBKE is linked to systemic lupus erythematosus.