Has-mir-10b-5p regulated SRSF1 transcription and down-regulated SRSF1 protein expression by inhibiting the 3’-UTR activity of SRSF1, resulting in T cell activity and enhanced autoimmunity.401 The expression of has-miR-10b-5p in healthy women T cells was higher than that of healthy men, and the expression of has-miR-10b-5p in systemic lupus erythematosus patients T cells was also higher, resulting in immune response activation.401 In conclusion, DNA methylation, demethylation, and miRNA regulation of immune response may help explain sex differences in autoimmune diseases. This evidence concerns the gene SRSF1 and autoimmune disease.