In the Alzheimer’s disease model of mice expressing human APP (hAPP), the FCG model showed that the mortality and cognitive impairment of mice with XY- sex chromosome complement were more serious than those of XX.471 In humans, the genetic variant of KDM6A was expressed elevated in the brain and was linked to enhanced cognitive function in aging and preclinical Alzheimer’s disease, which in turn improved human brain health. Here, KDM6A is linked to Alzheimer disease.