SETD7 and obesity due to melanocortin 4 receptor deficiency: Set7 deletion mice did not develop obesity-induced glucose intolerance or decreased heart function recovery following ischemia/reperfusion injury.71 Set7 deletion female mice showed no decrease in left ventricular developed pressure, positive first derivative of left ventricular pressure (+dP/dT), or negative first derivative of left ventricular pressure (−dP/dT) during ischemia/reperfusion, unlike wild-type obese female mice.