SETD7 and obesity due to melanocortin 4 receptor deficiency: This is because Set7 deletion in female obesogenic diet mice rectified lower Bcl2 levels after heart ischemia/reperfusion, resulting in reduced cardiomyocyte apoptosis and improved cardiac recovery after ischemia/reperfusion.71 Further studies are needed to investigate the effect of Set7 in obesity-induced glucose homeostasis and insulin resistance.