Previous studies have found that sacubitril/valsartan can improve heart function and reduce hospitalization rates in female heart failure patients with preserved ejection fraction.114 As for β receptor blockers, carvedilol has more benefits in treating male heart failure, while metoprolol improves heart failure better in women.115 There is no sex difference in the treatment of heart failure with aldosterone receptor antagonists, sodium glucose cotransporter 2 inhibitors, ivabradine, and soluble guanylate cyclase agonists. The gene discussed is SLC5A2; the disease is heart failure.