KRT18 and Kallmann syndrome: Remarkably, K18-hACE2 mice support SARS-CoV-2 replication in the sinonasal epithelium, which is associated with pathology related to anosmia, a common feature of human disease.335–337 In addition, impaired lung function, including respiratory distress, markedly abnormal lung biomechanics, and labored breathing, was observed in K18-hACE2 mice.