Much attention has been given to ZIKV infection in pregnant women and the corresponding fetal microcephaly and other associated diseases.720,721 IV or SC infection of ZIKV-infected pregnant IFNAR1−/− C57BL/6 mice caused placental infection, fetal brain injury, and fetal death.722 When IFNAR1 female mice were mated with WT sires, the resulting fetuses were considered IFNAR1 heterozygotes. Here, IFNAR1 is linked to microcephaly.