As shown in Fig. 5, we observed a significant increase in the mRNA levels of PGC1-α (Fig. 5a), Drp1 (Fig. 5b) and SIRT3 (Fig. 5c) in whole blood of BS patients at both the six- and twelve-months post-weight loss time points, suggesting an improvement in terms of mitochondrial quality and health. Here, PPARGC1A is linked to Bloom syndrome.