CCR2 and myocardial infarction: In this context, monocytes serve as conduits of inflammation between the heart and the brain, interacting with oligodendrocytes in order to exacerbate neuroinflammation and drive white matter injury, with the aforementioned study also showing that blocking the ability of monocytes to infiltrate tissue with Ccr2. −/− mice prevents white matter injury and preserves cognitive function post-myocardial infarction (MI).