PDE4B and schizophrenia: Since GWAS data have associated PDE4B with PTSD (Gelernter et al., 2019; Meier et al., 2019; Nievergelt et al., 2024) and schizophrenia (Trubetskoy et al., 2022), which are often comorbid (Dallel et al., 2018), we subjected Pde4bM220T mice to several behavioral tests that examine a range of evolutionary conserved cognitive and behavioral domains.