PDE4B and stress-related disorder: The lead SNPs for stress-related disorders (Meier et al., 2019; Nievergelt et al., 2024) and addiction risk (Hatoum et al., 2023), and the site of DNA methylation (cg14227435) that correlates with PDE4B expression and re-experiencing symptom severity in PTSD patients (Hori et al., 2024), are all located in PDE4B intron 3, thus implicating the long forms over the short forms.