IL6 and chronic rhinosinusitis: Interleukin-6 (IL-6) is a cytokine with a pathogenic role in chronic rhinosinusitis,6 which stimulates fibroblast proliferation and collagen production, decreasing collagen degradation in the extracellular matrix.7, 8 Moreover, IL-6 leads to an adaptative chronic inflammatory reaction, T cell recruitment and survival.7, 9 The inflammation pathway has acquired relevance for clinical practice.