At the same time, the neurodegeneration field has generated myriad studies linking Alzheimer’s disease susceptibility and AD pathology signatures such as extracellular accumulation of amyloid-β protein and/or intracellular accumulation of tau as outcomes of mechanical stress-based stimuli such as traumatic brain injury, arterial hypertension, and normal pressure hydrocephalus (Ramos-Cejudo et al., 2018; Malone et al., 2022). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.