APP and Alzheimer disease: Examples of recent implication of mechanical stimuli in AD-related outcomes include that stretch in the brain vascular system can increase APP and B-secretase expression to increase Aβ production (Gangoda et al., 2018) and that microglial mechanosensing via the Piezo1 mechanotransducing channel limits progression of Aβ pathology in mouse models (Hu et al., 2023).