APOE and endometriosis: Pid1, Saa3, Apoe, and Lrp1 were key DEGs in the monocyte-derived LpM population (Fig. 4A), and qPCR analysis also confirmed an upregulation of these genes in Tim4− peritoneal macrophages isolated from mice with induced endometriosis compared to those without (Saa3, Lrp1,P < 0.01; Fig. 4B).