Hierarchical clustering (Supplementary Figure S12) and multi-dimensional scaling (Supplementary Figure S13) found that SB/AKT/c-Met + TAA and SB/AKT/NRas + TAA formed a distinct cluster; the cancer plasmids-TAA combinations were more similar to each other than to their respective cancer plasmids without TAA or TAA alone groups. The gene discussed is NRAS; the disease is cancer.