Complement activation in the TME orchestrates the recruitment of myeloid‐derived suppressor cells (MDSCs), neutrophils, and tumor‐associated macrophages (TAMs), establishing a pro‐survival milieu.[32] Analysis via the TIMER database revealed significant positive correlations between the expression of C1r or C3 and M2‐macrophage infiltration in PAAD or LUSC patients (Figure S6C, Supporting Information). Here, C3 is linked to pancreatic adenocarcinoma.