Interestingly, the expression of C1r and C3a was reduced in a time‐dependent manner by AZD4573 in the AML cell line MV‐4‐11, as was the downregulation of c‐Myc and p‐ERK (Figure S7F, Supporting Information), which contradicted the effects observed in solid cancers, such as PDAC. Here, C3 is linked to acute myeloid leukemia.