Down‐regulated genes in the tumor microenvironment pathway included fibroblast growth factors and vascular endothelial growth factors (FGF1, FGF5, FGF7, FGF10, and VEGFD), regulating angiogenesis, transforming growth factor beta genes (TGFB2 and TGFB3), regulating epithelial mesenchymal transition and cytotoxic T lymphocytes and Insulin growth factor 1 (IGF1), regulating cancer cell invasion and metastasis (Figure 6C,D). This evidence concerns the gene IGF1 and neoplasm.