In addition, the upregulation of immune check‐points (ICs), such as PD‐1, TIM‐3, CTLA‐4, LAG‐3, and TIGIT on CD8 T cells has been identified in de novo AML and relapsed and refractory AML (R/R AML).45, 46, 47, 48, 49. The gene discussed is CTLA4; the disease is acute myeloid leukemia.