In vitro experiments have shown that apigenin impacts regulatory molecules by repressing the STAT3 and NF‐κB, which are involved in the expression of adhesion molecules, enzymes, angiogenesis factors (e.g., VEGF‐C, MMP‐2/MMP‐9, E‐cadherin) and chemokines (e.g., CXCR4) responsible for malignant behaviors of CRC.13, 39, 49, 55. This evidence concerns the gene CDH1 and colorectal carcinoma.