To investigate the effects of paternal hypercholesterolemia on offspring cardiometabolic health, 3-week-old male LDLR–/– mice were fed a low-fat AIN76 diet (4.3% fat) containing either 0.02% or 0.5% cholesterol for 8 weeks before mating with age-matched control LDLR–/– female mice (42, 43) (Figure 1A). The gene discussed is LDLR; the disease is familial hypercholesterolemia.