We found that higher baseline plasma levels of P-tau181 (β = −0.49, p = 2.53 × 10−5), NfL (β = −0.29, p = 0.01), and GFAP (β = −0.60, p = 1.99 × 10−7) were associated with faster cognitive decline, but no association was found with baseline plasma Aβ42/Aβ40 ratio (β = 0.10, p = 0.40) (Fig. 2, Supplementary Table S1). The gene discussed is NEFL; the disease is Mental deterioration.