CACNB2 and epilepsy: On the other hand, one study demonstrated Cavβ4 is associated with the lethargic mouse model of epilepsy (Burgess et al., 1997; Vergnol et al., 2022), while another study showed that disruption in the Cavβ2 gene leads to diminished L-type channel currents (Weissgerber et al., 2006).