Further investigation will determine whether hs-cTnT levels may help identify individuals with HIV who are more likely to develop incident ASCVD and who would benefit from primary prevention treatment strategies.PerspectivesCOMPETENCY IN MEDICAL KNOWLEDGE: To what extent do levels of the circulating biomarker cardiac troponin T, a measure of myocyte injury and cell death, associate with presence of subclinical coronary plaque and high-risk plaque characteristics in PWH who are asymptomatic, without known ASCVD, and low-to-moderate traditional risk. This evidence concerns the gene TNNT2 and atherosclerosis.