Kim et al. utilized transferrin receptor (TfR)-modified exosomes to construct TfR-exo, and by coupling the T7 peptide to Lamp2b, compared to the unmodified exosome, TfR-exo had favorable BBB penetration and glioma targeting (Kim et al., 2020; Choi et al., 2022). This evidence concerns the gene TFRC and central nervous system cancer.