SLC2A1 and neoplasm: Glucose transporters (e.g., GLUT1) are highly expressed on brain capillary endothelial cells and various tumor cells, including brain tumors, while glucose is a principal source of energy for brain and tumor hypermetabolism; thus, surface-loaded glucose ligands enable sequential dual-targeted delivery of therapeutic agents (Abbott, 2002; Serrano et al., 2012).