The results showed that bisphenol A, Benzo(a)pyrene, Tetrachlorodibenzodioxin and tobacco smoke pollution can be effective drugs to inhibit these genes in the PI3K-AKT pathway (Fig. 6), and that these compounds were considered as the candidate drugs for PCOS and RSA treatment and intervention. The gene discussed is AKT1; the disease is polycystic ovary syndrome.