For deubiquitinating enzyme inhibitors, in a study of a mouse lung cancer model, it was found that the combination of USP7 inhibitor P5091 and adenovirus vaccine significantly increased infiltration of tumor-specific CD8+ T cells and IFN-γ production with reduced accumulation of Foxp3+ Treg cells in the tumor, resulting in a significant limitation of tumor growth.161. The gene discussed is CD8A; the disease is neoplasm.