For example, for the regulation of tumor-associated macrophages and resident memory T cells, targeting the macrophage marker F4/80, CAR-T cells can target tumor-associated macrophages to suppress them and provide enhancement of tumor immunity,108 and CAR-T cells targeting CXCR6 can regulate resident memory T cells and thus modulate tumor immunity.109. The gene discussed is CXCR6; the disease is neoplasm.