PORCN and neoplasm: Recent studies have found that β-catenin levels are associated with T cell rejection and tumor growth, that immune cell infiltration in the ovarian cancer tumor microenvironment can be regulated by modulating signal transduction in the Wnt pathway, that the PORCN inhibitor CGX-1321 increases infiltration of CD8+ T cells into the tumor microenvironment, and that DDK1 overexpresses myeloid-derived suppressor cells to promote immune evasion.129