E3 enzyme DTX3 (also known as RNF154) mediates ubiquitination of mtp53 and maintains stability of mtp53 by preventing MDM2-mediated ubiquitinated degradation of mtp53, thus exerting the pro-oncogenic effect of mtp53 to promote the growth and proliferation of ovarian cancer cells.98 The gene discussed is DTX3; the disease is ovarian cancer.