It was found that SYMD3 interacts with the E2 enzyme UBE2R2 to promote the ubiquitinated degradation of p53, thereby promoting the metastasis of ovarian cancer and enhancing the migration of epithelial ovarian cancer cells, hypothesizing that SYMD3 may have a similar function to that of E3 enzymes.97 Here, TP53 is linked to ovarian carcinoma.