The E2 enzyme UBE2S is up-regulated in high-grade serous ovarian cancer, and the E2 enzyme UBE2S forms a complex with the E3 enzyme APC/C to promote the formation of a K11-linked ubiquitin chain from the k19 residue of the β-catenin, facilitating its accumulation in the cytoplasm and translocation to the nucleus, thereby activating the Wnt signaling pathway.134. This evidence concerns the gene UBE2S and ovarian serous adenocarcinoma.