JAK1 and neoplasm: The above ubiquitination process regulates STING signaling, which can further affect the activation of type I interferon under STING signaling, thereby influencing the inflammatory response in the tumor microenvironment.54, 55, 56 In addition, the E3 ubiquitin ligase STUB1 can directly mediate the ubiquitin-dependent proteasomal degradation of the IFNγ-R1/JAK1 complex, thereby inhibiting interferon-mediated inflammatory responses.57