CUL3 and ovarian cancer: Other E3 ubiquitin ligases, like cullin 3, also promote ovarian cancer development through the ubiquitinated degradation of their substrates.13, 14, 15, 16 In addition, there are also E3 ubiquitin ligases that can inhibit the development of ovarian cancer, such as FBXO16, which also depends on the degradation of the substrate by its ubiquitin ligase activity.17