In this sense, even though the TNF-α/IL-10 ratio did not show a difference between the volunteer group, the higher IL-6/IL-10 ratio found in the group with diabetes, at baseline (T0) and post-treatment (T1), in conjunction with the higher IFN-γ/IL-10 ratio found at baseline (T0), than the values observed in the group without diabetes indicates that a prominent pro-inflammatory status was present in the diabetic individuals. The gene discussed is IFNG; the disease is diabetes mellitus.