Beyond these pro-inflammatory cytokines, the classical anti-inflammatory cytokine IL-10 has been also studied in the diabetes and periodontitis context (24), and, in general, it was reported that both patients with periodontitis and type-2 diabetes and patients with periodontitis but not diabetics presented lower IL-10 levels than in control groups (24–26). This evidence concerns the gene IL10 and type 2 diabetes mellitus.