Hyperglycemia increases the production of reactive oxygen species (ROS) in the vessel wall, triggering a series of events: activation of the polyol and hexosamine pathways, formation of advanced glycation end products (AGEs), activation of protein kinase C (PKC) pathways, and increased nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity. This evidence concerns the gene PRRT2 and Hyperglycemia.