Notably, m6A alteration mediates YTHDC2's action as a tumor suppressor via the CYLD/NF-κB pathway, indicating a crucial connection between smoking-related YTHDC2 downregulation and accelerated lung cancer development (Wang et al., 2021[192]) (Figure 3(Fig. 3)). The gene discussed is NFKB1; the disease is lung carcinoma.