For example, inhibition of IGF-1R (insulin like growth factor-1 receptor) downregulates sCLU (Criswell et al., 2005[28]), ascorbate suppresses CLU and induces apoptosis in melanoma cells (Mustafi et al., 2017[110]), and, finally, miR-378 suppresses CLU and increases chemosensitization in non-small cell lung cancer (Chen et al., 2016[19]) (Figure 5(Fig. 5)). The gene discussed is IGF1R; the disease is melanoma.