These include the protease inhibitor SERPINB7 for LUAD, angiogenesis-associated growth factor VEGFC for PDAC, key developmental transcription factor SOX4 for LSCC, homeobox protein HOXB4 for UCEC, cell-cell adhesion glycoprotein CDH4 for CCRCC and Ras oncogene family member RAB40C in HNSCC. The gene discussed is HOXB4; the disease is head and neck squamous cell carcinoma.