LRRK2 and Parkinson disease: To study how the LRRK2 G2019S mutation impacts astrocytes in the prefrontal cortex, a cortical region linked to PD, we stained sections from the frontal cortices of age and sex-matched control and LRRK2 G2019S mutation-carrying PD patients (Supplemental Table 1) with glial fibrillary acidic protein (GFAP, a marker for astrocyte branches) and phosphorylated ERM (Phospho-ERM, which are enriched in PAPs) (Figure 1A).