Metabolic acidosis, a common complication of CKD, correlates with severe consequences, such as potential for CKD advancement (Madias, 2021), breakdown of skeletal muscles, resistance to insulin, loss of bone mineralization, and elevated mortality (Kovesdy, 2014; Garibotto et al., 2015; Bellasi et al., 2016; Raphael, 2019). Here, INS is linked to chronic kidney disease.