Since endocannabinoids increase Kir2.1 conductance, we considered as proof of concept if enriching endocannabinoids could be useful in enhancing Kir2.1 mutant channels linked to LQT7 or Andersen-Tawil Syndrome. The gene discussed is KCNJ2; the disease is Cardiodysrhythmic potassium-sensitive periodic paralysis.