DLG4 and major depressive disorder: Kong et al. (2023) conducted a study comparing the antidepressant effects of OA and UA, and found that in a depression model induced by CMS, OA was more effective than UA at reversing the depressive-like behavior induced by MS. In their mechanistic study, it was found that both OA and UA treatments reversed the decrease in synapsin expression levels caused by MS, but only OA upregulated the expression level of PSD-95 (Kong et al., 2023).