In mice with LPS-induced depression, quercitrin intervention could improve hippocampal damage, restore the abnormal expression of the pCREB/BDNF/PSD95/Synapsin1 pathway, regulates the PI3K/AKT/NF-κB signaling pathway, and enhances neuroplasticity (Sun et al., 2021). This evidence concerns the gene NFKB1 and major depressive disorder.