Fan et al. (2022) found that the antidepressant mechanism of Honokiol involved the activation of the HIF-1α/VEGF signaling pathway and the upregulation of synaptic protein one and PSD 95 expression levels. Salidroside, an active metabolites found in Rhodiola rosea L. used in TCM, has various pharmacological effects (Xue et al., 2019). It enhances BDNF expression, improve synaptic plasticity, and inhibits pyroptosis mediated by the P2X7/NF-κB/NLRP3 signaling pathway, thereby providing a treatment for depression (Chai et al., 2022). Here, BDNF is linked to major depressive disorder.