Diabetes is a chronic and non-communicable disorder with an increasing incidence worldwide that is estimated to reach 783 million cases by 2045.1 In recent times, diabetes has been classified into four categories: type 1 diabetes (T1D, destruction of β-cell), type 2 diabetes (T2D, losing of β-cell insulin secretion), gestational diabetes, and diabetes due to alternative factors (monogenic diabetes syndromes, disease related to the exocrine pancreas or induced by drugs/chemicals after HIV/AIDS management by glucocorticoids or following organ transplantation.2 The gene discussed is INS; the disease is type 2 diabetes mellitus.