The FTO gene cipher a Fe II 2-oxoglutarate dependent demethylase enzyme that cuts the methyl group present in various positions of DNA as well as RNA and it is expressed in the arcuate nucleus of the hypothalamus playing a key role in the mechanism of energy intake and energy expenditure.14 Several studies have examined a remarkable correlation between obesity risk and polymorphisms of the FTO gene.15-19 The current study depicts two intronic variants of the FTO gene 30685T/G (rs17817449) and -23525T/A (rs9939609). This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.